BDBM50567345 CHEMBL4872913

SMILES c1ccc(c(c1)/C=C/C(=O)NO)Sc2ccc(cc2)Cl

InChI Key InChIKey=LOPNSVKBMZZEHH-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50567345   

TargetHistone deacetylase 8(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 180nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of human HDAC1 (1 to 482 reidue) expressed in sf9 cells using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by tryps...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human HDAC6 using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition and measured after 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 180nMAssay Description:Inhibition of human HDAC8 using using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed