BDBM50566278 CHEMBL4867353

SMILES OC(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1

InChI Key InChIKey=WEBVQIJGIZVRGA-UHFFFAOYSA-N

Data  7 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50566278   

TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at STING in human THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataEC50:  3.03E+3nMAssay Description:Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataIC50: 9.81E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant wild type STING CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataIC50: 6.16E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING R232H mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataIC50: 1.39E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING G230A/R293Q double mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataIC50: 8.02E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING R293Q mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataIC50: 1.60E+3nMAssay Description:Agonist activity at mouse 6His-tagged recombinant STING CTD (144 to 378 residues) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataEC50:  1.35E+5nMAssay Description:Agonist activity at mouse STING in mouse RAW-Lucia ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human STING in STING knockout human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataEC50: >2.00E+5nMAssay Description:Agonist activity at mouse STING in STING knockout mouse RAW-Lucia ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataEC50:  2.36E+3nMAssay Description:Agonist activity at STING in PMA-differentiated wildtype human THP1-Blue ISG cells harboring IRF-inducible SEAP reporter construct incubated for 24 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataIC50: 2.20E+3nMAssay Description:Competitive inhibition of 5-FAM labelled diABZI binding to recombinant 6-his tagged mouse STING C-terminal domain (144 to 378 residues) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in PMA-differentiated human THP1-Dual KO-STING cells incubated for 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50566278(CHEMBL4867353)
Affinity DataIC50: 7.80E+3nMAssay Description:Binding affinity to wild type human STING by HTRF based cGAMP competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed