BDBM50559636 CHEMBL4760447

SMILES COc1cccc(F)c1-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCN(C)CC1

InChI Key InChIKey=KAOYHQWWTGUIBS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50559636   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50559636(CHEMBL4760447)Copy SMILESCopy InChI

Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HPK1 in human PBMC assessed as inhibition of SLP76 phosphorylation by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
Copy Entry DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50559636(CHEMBL4760447)Copy SMILESCopy InChI

Affinity DataIC50: 2.60nMAssay Description:Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL