BDBM50559631 CHEMBL4754671

SMILES CN1CCN(CC1)c1ccc(cc1)-n1ncc2cc(C#N)c(cc12)-c1c(C)cccc1F

InChI Key InChIKey=YCDUCYZVJNKJTL-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50559631   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50559631(CHEMBL4754671)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HPK1 in human PBMC assessed as inhibition of SLP76 phosphorylation by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50559631(CHEMBL4754671)Copy SMILESCopy InChI

Affinity DataIC50: 28nMAssay Description:Displacement of Tracer 222 from N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues ) expressed in baculovirus-infected Sf9 cells incubat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL