BDBM50553416 CHEMBL4755663

SMILES CC(C)(C)c1ccc(cc1)C(=O)NCc1ccc(cc1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=ODLDMAFDYHTWSE-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50553416   

TargetTyrosine-protein kinase BTK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50553416(CHEMBL4755663)
Affinity DataIC50: 142nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged BTK expressed in baculovirus infected Sf21 insect cells using fluorescein-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553416(CHEMBL4755663)
Affinity DataKd:  82nMAssay Description:Binding affinity to wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553416(CHEMBL4755663)
Affinity DataKd:  150nMAssay Description:Binding affinity to wild-type human partial length KIT (I571 to D952 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553416(CHEMBL4755663)
Affinity DataKd:  53nMAssay Description:Binding affinity to wild-type human partial length PDGFRB (V582 to Y1009 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553416(CHEMBL4755663)
Affinity DataKd:  160nMAssay Description:Binding affinity to wild-type human partial length YSK4 (T1019 to H1328 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed