BDBM50550673 CHEMBL4745255

SMILES C[C@H](CN1CCOCC1)Oc2ccc3c(c2)Cc4cccc(c4S3)C5=CC(=O)C=C(O5)N6CCOCC6

InChI Key InChIKey=HRZBUHAVTBTHTM-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50550673   

TargetSerine-protein kinase ATM(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50: 70nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant full-length human VPS34 incubated for 60 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA-dependent protein kinase catalytic subunit(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50: 82nMAssay Description:Inhibition of DNA-PK isolated from human HeLa cells assessed as reduction in p53 Ser15 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed