BDBM50550618 CHEMBL4778859

SMILES Nc1ncc(cc1-c1ccc(Cl)cc1)-c1ccc(cc1)C1(CCCC1)C(O)=O

InChI Key InChIKey=VHQILBJBMFWZGW-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50550618   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50550618(CHEMBL4778859)Copy SMILESCopy InChI

Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy Entry DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50550618(CHEMBL4778859)Copy SMILESCopy InChI

Affinity DataIC50: 148nMAssay Description:Inhibition of MAP4K4 in human GripTite 293 MSR cells assessed as reduction in TRAF2 Ser/Thr phosphorylation incubated for 1.5 hrs by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL