BDBM50547750 CHEMBL4800314

SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCCC(C1)c1ccnc2ncnn12

InChI Key InChIKey=QRHYHQMFAMRYKQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50547750   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE4D3 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE1B1 expressed in HEK cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 66nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 551nMAssay Description:Inhibition of 6xHis-tagged rat recombinant PDE10A2 expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE7A1 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE9A1 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547750(CHEMBL4800314)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE11A4 expressed in HEK cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed