BDBM50547002 CHEMBL4753379::US11247971, Cmpd ID 449::US11752138, Compound 112

SMILES Cc1ccc(s1)C#Cc1cccc(c1)-c1nn(c(CC2CC2)c1Cc1ccc(c(F)c1)S(N)(=O)=O)-c1nc(cs1)C(O)=O

InChI Key InChIKey=LZIKVHXLVMNROK-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50547002   

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataIC50: 119nMAssay Description:Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataKd:  0.0634nMAssay Description:Binding affinity to human His-tagged LDHA by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataIC50: 760nMAssay Description:Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataIC50: 367nMAssay Description:Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataIC50: 100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
Go to US Patent

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human LDHAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50547002(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human LDHBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed