BDBM50546390 CHEMBL4757869::US20240122876, Example 2

SMILES CC1=C(C(CCC1)(C)C)COc2cccc(c2)[C@@H](CCN)O

InChI Key InChIKey=IMAIQFBFQHDLHJ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50546390   

TargetRetinoid isomerohydrolase(Bovine)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50546390(CHEMBL4757869 | US20240122876, Example 2)
Affinity DataEC50:  323nMAssay Description:Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production using all-trans-retinol as substrate pre-incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoid isomerohydrolase(Bovine)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50546390(CHEMBL4757869 | US20240122876, Example 2)
Affinity DataIC50: 323nMAssay Description:Inhibition of RPE65 in bovine retinal pigment epithelium microsomes assessed as decrease of 11-cis-retinol using trans-retinol measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoid isomerohydrolase/Retinaldehyde-binding protein 1(Human)
Case Western Reserve University

US Patent
LigandPNGBDBM50546390(CHEMBL4757869 | US20240122876, Example 2)
Affinity DataIC50: 323nMAssay Description:Primary amine listed in Table 2 in DMF (1 μL) was added into a suspension containing 300 μg of RPE microsomal proteins, 1% bovine serum alb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)