BDBM50546210 CHEMBL1434615

SMILES COc1cccc(-c2nnc3n(Cc4ccccc4Cl)c(=O)c4ccccc4n23)c1O

InChI Key InChIKey=MUHNHVCFKYIXPU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50546210   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of SHP2 ( 1 to 525 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SHP2 PTP domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 6.00E+4nMAssay Description:Allosteric inhibition of IRS1_pY1172(dPEG8)pY1222 activated-human full length SHP2 (Met1 to Leu525 residues) expressed in Escherichia coli BL21 Star ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of 6His-tagged TEV protease fused human SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 star (DE3) using DiFMUP as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of SHP2 T253M/Q257L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of SHP2 1-525 mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed