BDBM50545460 CHEMBL4641667

SMILES CCNS(=O)(=O)c1ccccc1Nc2ncnc(n2)Nc3ccc(c(c3)OC)N4CCC(CC4)N5CCN(CC5)C

InChI Key InChIKey=YJUANBRSJHPDHJ-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50545460   

TargetFibroblast growth factor receptor 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50545460(CHEMBL4641667)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged human FGFR3 cytoplasmic domain (436-806 end amino acids residues) expressed in baculovirus expression system prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50545460(CHEMBL4641667)
Affinity DataIC50: 266nMAssay Description:Inhibition of N-terminal GST-tagged human VEGFR2 cytoplasmic domain (790-1356 end amino acid residue) expressed in baculovirus expression system prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50545460(CHEMBL4641667)
Affinity DataIC50: 40nMAssay Description:Inhibition of N-terminal GST-tagged human FGFR1 cytoplasmic domain (398-822 end amino acids residues) expressed in baculovirus expression system prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50545460(CHEMBL4641667)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of N-terminal GST-tagged human FGFR2 cytoplasmic domain (399-821 end amino acids residues) expressed in baculovirus expression system prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50545460(CHEMBL4641667)
Affinity DataIC50: 682nMAssay Description:Inhibition of N-terminal GST-tagged human FGFR4 cytoplasmic domain (460-802 end amino acids residues) expressed in baculovirus expression system prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed