BDBM50541929 CHEMBL1738785

SMILES Cn1cnc2c1C(=O)N(C(=O)N2C)CCCN3C(=O)c4c([nH]cn4)N(C3=O)C

InChI Key InChIKey=PUHJHZQYIBJCSQ-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50541929   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541929(CHEMBL1738785)
Affinity DataIC50: 920nMAssay Description:Inhibition of human acidic mammalian chitinase using 4-methylumbelliferyl-beta-D-N,N',N''-diacetylchitobioside and 4-methylumbelliferyl-beta-D-N,N',N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541929(CHEMBL1738785)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of human CHIT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541929(CHEMBL1738785)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human CHIT1 using 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotriose as substrate assessed as substrate hydrolysis by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50541929(CHEMBL1738785)
Affinity DataKi:  260nMAssay Description:Inhibition of human AMCase using 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotriose as substrate assessed as substrate hydrolysis by measuring...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)