BDBM50537600 CHEMBL4129018::US11149020, Compound 27 (MW-150)

SMILES CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1

InChI Key InChIKey=CIIVUDIZZJLXCN-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50537600   

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataIC50: 282nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataIC50: 2.80E+3nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataIC50: 230nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataIC50: 2.61E+3nMAssay Description:Inhibition of human CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataIC50: 230nMAssay Description:Antagonist activity at p38 MAPK alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataKi:  100nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537600(CHEMBL4129018 | US11149020, Compound 27 (MW-150))
Affinity DataKi:  101nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent