BDBM50533679 CHEMBL4473316

SMILES C[C@H]1CN(C[C@@H](C)N1)c1ncc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=SKFRRNOLFFQBQU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50533679   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50533679(CHEMBL4473316)
Affinity DataIC50: 1.20E+4nMAssay Description:Negative allosteric modulator activity at SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50533679(CHEMBL4473316)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SHP2 PTP domain (237 to 529 residues) by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50533679(CHEMBL4473316)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50533679(CHEMBL4473316)
Affinity DataIC50: 1.20E+4nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50533679(CHEMBL4473316)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed