BDBM50532616 CHEMBL4532382

SMILES CNc1nccc(n1)N2CC[C@@H](C2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)CN4CCOCC4

InChI Key InChIKey=LVIYMOOJJGCMCP-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50532616   

TargetCyclin-C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50: 17nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50: 17nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)