BDBM50531593 CHEMBL4555842

SMILES CC(C)Cc1cc2c(cc1F)OC[C@@H](N2C(=O)c3ccc4c(c3)NC(=O)CO4)CC(=O)NC

InChI Key InChIKey=OUCNRPREOGLYEL-UHFFFAOYSA-N

Data  2 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50531593   

TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531593(CHEMBL4555842)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531593(CHEMBL4555842)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50531593(CHEMBL4555842)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to recombinant human GR LBD by fluormone GS red-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed