BDBM50530797 CHEMBL4467503

SMILES OCCn1c2cnc(nc2n(C2CCOCC2)c1=O)-c1cnc2ccc(cn12)C#N

InChI Key InChIKey=RJIVCYWQVNETLQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50530797   

TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530797(CHEMBL4467503)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530797(CHEMBL4467503)
Affinity DataIC50: 850nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530797(CHEMBL4467503)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530797(CHEMBL4467503)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530797(CHEMBL4467503)
Affinity DataIC50: 850nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530797(CHEMBL4467503)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed