BDBM50528943 CHEMBL4562561

SMILES c1cc(ccc1Cc2c[nH]c3c2C(=O)NC(=N3)N)C(=O)Nc4cc(ccc4C(=O)O)C(=O)O

InChI Key InChIKey=UKZJDHHDTGYQBX-UHFFFAOYSA-N

Data  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50528943   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50528943(CHEMBL4562561)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant Cryptosporidium hominis TS-DHFR expresssed in Escherichia coli PA414 using dUMP and 5,10-methylenetetrahydrofolate as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50528943(CHEMBL4562561)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed