BDBM50528194 CHEMBL4517408

SMILES COc1cc(cc(OC)c1OC)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=RKBYYWVZFBATHQ-UHFFFAOYSA-N

Data  36 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50528194   

TargetCytochrome P450 2B6(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate incubated for 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMisshapen-like kinase 1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 336nMAssay Description:Inhibition of MINK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 336nMAssay Description:Inhibition of NLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 336nMAssay Description:Inhibition of SIK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 20(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 336nMAssay Description:Inhibition of ZAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of recombinant human CB1 incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of recombinant human adrenergic alpha2A receptor incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells after 5 mins by IonWorks barracuda patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 41nMAssay Description:Inhibition of DDR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate incubated for 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate incubated for 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate incubated for 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate incubated for 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 96nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 16nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 G356D mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 13nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 8nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 13nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin) by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 45nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 6nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 G328V mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 13nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 7nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 Q207D mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 12nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 R206H mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 15nMAssay Description:Inhibition of human ALK1 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 428nMAssay Description:Inhibition of human ALK3 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human ALK4 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 68nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 336nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 336nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed