BDBM50527733 CHEMBL4552922

SMILES C[C@@](C#Cc1ccc2c(c1)N(CC2)c3c(cnc(n3)N)Cl)(c4nccs4)O

InChI Key InChIKey=OKFYOOFXVBCIIP-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50527733   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50527733(CHEMBL4552922)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NIK (318 to 947 residues) expressed in baculovirus infected Sf9 cells using ultrapure ATP as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 14(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50527733(CHEMBL4552922)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human NIK using ATP as substrate by kinase-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)