BDBM50527098 CHEMBL4446834

SMILES B([C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)c3cc(ccc3Cl)Cl)(O)O

InChI Key InChIKey=OIYFPOOZLADOLC-UHFFFAOYSA-N

Data  1 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50527098   

TargetATP-dependent Clp protease proteolytic subunit(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527098(CHEMBL4446834)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocyte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetATP-dependent Clp protease proteolytic subunit(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527098(CHEMBL4446834)
Affinity DataEC50:  1.27E+3nMAssay Description:Binding affinity to N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) assessed as shifting o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetATP-dependent Clp protease proteolytic subunit(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527098(CHEMBL4446834)
Affinity DataIC50: 900nMAssay Description:Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed