BDBM50524996 CHEMBL4573171::US11401286, Example 65

SMILES CCc1cc(Cc2ccc(CC(N)=O)cc2)nc(n1)-c1cccc(Cl)c1

InChI Key InChIKey=FUJWOWGJBPZCTE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50524996   

TargetCytochrome P450 2C19(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYPC19 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 225nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D7 [S54D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

TargetIsoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50524996(CHEMBL4573171 | US11401286, Example 65)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent