BDBM50524862 CHEMBL4475680

SMILES c1cc2c(cc1N3CC[C@@](C3=O)(C(=O)NCc4cc(cc(c4)Cl)F)O)CCC(=O)N2

InChI Key InChIKey=RMWSKRBLJAUOOY-UHFFFAOYSA-N

Data  2 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50524862   

TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and manganese as co-facor preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and cobalt as co-facor preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 15nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 15nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataKi:  0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataKi:  0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)