BDBM50521216 CHEMBL4474208

SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1ccncc1

InChI Key InChIKey=KDSFLYIZGIJKAW-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50521216   

TargetAurora kinase B(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetTyrosine-protein kinase ITK/TSK(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetRho-associated protein kinase 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetTyrosine-protein kinase JAK3(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetMitogen-activated protein kinase 10(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetEpidermal growth factor receptor(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 251nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 794nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HTR...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase JAK2(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50521216(CHEMBL4474208)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL