BDBM50519610 CHEMBL4533049

SMILES c1cc2c(cc1C(=O)O)N(C[C@@H](CO2)c3ccc(cc3Cl)Cl)CC4CCC4

InChI Key InChIKey=FLTAOBQLOVJBJL-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50519610   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519610(CHEMBL4533049)
Affinity DataIC50: 300nMAssay Description:Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519610(CHEMBL4533049)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and TAMRA labeled Bim BH3 peptide interaction us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Caen Normandy

Curated by ChEMBL
LigandPNGBDBM50519610(CHEMBL4533049)
Affinity DataIC50: 300nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)