BDBM50516382 CHEMBL4436895

SMILES c1cc(c(c(c1)Br)C(=O)c2cc([nH]c2)C(=O)Nc3cccnc3)F

InChI Key InChIKey=ATKCERYALDNMPL-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50516382   

TargetCytochrome P450 3A4(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HA-tagged ERK5 (unknown origin) coexpressed with mutationally activated EGFP-MEK5D and Gal4-MEF2D in HEK293 cells assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full length human p38alpha expressed in Escherichia coli cells assessed as substrate phosphorylation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 820nMAssay Description:Inhibition of human recombinant N-terminal His-tagged / TEV cleavage site fused ERK5 (2 to 409 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)