BDBM50514216 CHEMBL4528051::US11274105, Example 5

SMILES CN1CC/C=C/[C@@H]([C@@H]2CC[C@H]2CN3C[C@@]4(CCCc5c4ccc(c5)Cl)COc6c3cc(cc6)[C@](CC1=O)(C(=O)NS(=O)(=O)N(C)C)O)OC

InChI Key InChIKey=ODNXKGMGHYJKEY-UHFFFAOYSA-N

Data  3 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50514216   

LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataIC50: 0.280nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataIC50: 4.20nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataIC50: 0.980nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataIC50: 24.7nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataKi:  0.0970nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataKi:  0.100nMAssay Description:Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50514216(CHEMBL4528051 | US11274105, Example 5)
Affinity DataKi:  0.368nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)