BDBM50511879 CHEMBL4466553

SMILES Cc1cc(cc(c1OCCN2CCCC2)C)C3=Nc4cc(cc(c4C(=O)N3)OC)OC

InChI Key InChIKey=PQZDYFRDRHRZGF-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50511879   

TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 20nMAssay Description:Inhibition of biotinylated H4 peptide binding to recombinant N-terminal Hist-tagged BRD4 BD2 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of biotinylated H4 peptide binding to recombinant N-terminal Hist-tagged BRD4 BD1 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 beta(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of IL-1beta in mouse BMDM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of IL-17 in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of BRD4 BD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 20nMAssay Description:Inhibition of BRD4 BD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)