BDBM50511566 CHEMBL4448872

SMILES c1c(cc(c2c1N(CC23CCN(CC3)C4=NC5=C(CCCC5)C(=O)N4)CCO)F)F

InChI Key InChIKey=FZQYCOUBRJEYBC-UHFFFAOYSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50511566   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant TNKS2More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/21/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Srinath College of Pharmacy

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant TNKS1More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/21/2024
Entry Details
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase 2(Human)
University of South Australia

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of PAPR2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/21/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase 1(Human)
University of South Australia

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/21/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/21/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Srinath College of Pharmacy

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/21/2023
Entry Details
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Srinath College of Pharmacy

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase 2(Human)
University of South Australia

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 78nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase 1(Human)
University of South Australia

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 78nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase 1(Human)
University of South Australia

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Srinath College of Pharmacy

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Riken

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPoly [ADP-ribose] polymerase 2(Human)
University of South Australia

Curated by ChEMBL

LigandBDBM50511566(CHEMBL4448872)Copy SMILESCopy InChI

Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL