BDBM50511349 CHEMBL4475494::US10988478, Example 139

SMILES CC(C)([C@@H](CN1Cc2cc(c(cc2C1=O)N3CCOCC3)NC(=O)c4cnn5c4nccc5)F)O

InChI Key InChIKey=AUYCSWFYKYVCLD-UHFFFAOYSA-N

Data  2 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50511349   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50511349(CHEMBL4475494 | US10988478, Example 139)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50511349(CHEMBL4475494 | US10988478, Example 139)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant full-length N-terminal His6-tagged human IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50511349(CHEMBL4475494 | US10988478, Example 139)
Affinity DataKi:  1.5nMAssay Description:Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)