BDBM50511109 Cilofexor::GS 9674::Gs-9674::PX-104::PX104::US12215098, Compound PX-104

SMILES OC(=O)c1ccnc(c1)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl

InChI Key InChIKey=KZSKGLFYQAYZCO-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50511109   

TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  65.2nMAssay Description:Purpose of the Assay:Activation of FXR binding reaction by the compound was detected by the amplified luminescent proximity homogeneous assay (alphas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2025
Entry Details
Go to US Patent