BDBM50508293 Doravirine::MK-1439::Pifeltro

SMILES CN1C(=NNC1=O)CN2C=CC(=C(C2=O)Oc3cc(cc(c3)Cl)C#N)C(F)(F)F

InChI Key InChIKey=ZIAOVIPSKUPPQW-UHFFFAOYSA-N

Data  3 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50508293   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50508293(Doravirine | MK-1439 | Pifeltro)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation using poly(A)/oligo(dT)15 as templa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50508293(Doravirine | MK-1439 | Pifeltro)
Affinity DataIC50: 44nMAssay Description:Inhibition of wild type HIV-1 Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50508293(Doravirine | MK-1439 | Pifeltro)
Affinity DataIC50: 8.80E+4nMAssay Description:Inhibition of human ERG potassium channel expressed in CHO cells by automated patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed