BDBM50506054 CHEMBL4440185

SMILES C[C@@H](C(=O)OC(C)C)N(c1c(cccc1Cl)Cl)C(=O)c2ccco2

InChI Key InChIKey=QVXCXYZAVANRBK-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50506054   

TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506054(CHEMBL4440185)
Affinity DataIC50: 452nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506054(CHEMBL4440185)
Affinity DataIC50: 29nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)