BDBM50506046 CHEMBL4549748

SMILES Cc1c(nc(-c2ccc(Cl)o2)n1-c1c(Cl)ccc(N2CC(C2)C(O)=O)c1Cl)C(F)(F)F

InChI Key InChIKey=XHCGKVYORHHKEM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50506046   

TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506046(CHEMBL4549748)
Affinity DataIC50: 393nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506046(CHEMBL4549748)
Affinity DataIC50: 21nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed