BDBM50505741 CHEMBL4455718

SMILES COC(=O)N1CCN(CC1)C2CCC(CC2)Nc3c4cc(ccc4ncn3)C#N

InChI Key InChIKey=YCFRZMCRPHNZOC-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50505741   

TargetDual specificity protein kinase CLK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant CLK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 44nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 37nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of 5 mM ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 370nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant CDK8/cyclinC expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant CLK4 expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CLK3 expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 160nMAssay Description:Inhibition of IRAK4 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 7(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505741(CHEMBL4455718)
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant CLK2 expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed