BDBM50505255 BIIB-074::BIIB074::CNV-1014802::CNV1014802::GSK-1014802::GSK1014802::Raxatrigine::Vixotrigine

SMILES c1ccc(c(c1)COc2ccc(cc2)[C@H]3CC[C@H](N3)C(=O)N)F

InChI Key InChIKey=JESCETIFNOFKEU-UHFFFAOYSA-N

Data  1 KI  22 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50505255   

TargetCytochrome P450 2A6(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2A6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human Nav1.5 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of human Nav1.1 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in HEK293 cells assessed as inhibition of sodium current incubated for 3 to 3.5 mins by electrophysio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 7 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataKi: <1.00E+4nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed