BDBM50505177 CHEMBL4117175

SMILES CC(C)(C)c1cc2c(c(c1)F)C(=O)N(N=C2)c3cccc(c3CO)C4=NN(C(=O)C(=C4)Nc5ccc(cn5)C(=O)N6CCOCC6)C

InChI Key InChIKey=GLLQSOROVXWYRC-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50505177   

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50505177(CHEMBL4117175)
Affinity DataIC50: 1nMAssay Description:Inhibition of Kinase Tracer 178 binding to biotinylated-BTK (unknown origin) measured after 18 to 24 hrs by Europium-labeled Streptavidin conjugate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50505177(CHEMBL4117175)
Affinity DataIC50: 23nMAssay Description:Inhibition of BTK in goat F(ab')2 anti-human IgM-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50505177(CHEMBL4117175)
Affinity DataIC50: 23nMAssay Description:Inhibition of BTK in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)