BDBM50502640 CHEMBL4470585

SMILES C[C@@]1(CCC[C@]2(C1)CN(C(=O)O2)c3cnc(cn3)C(C)(C)O)Cn4cnc5c4cc(cc5)C#N

InChI Key InChIKey=URCMKDJBULWNAI-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50502640   

LigandPNGBDBM50502640(CHEMBL4470585)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50502640(CHEMBL4470585)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50502640(CHEMBL4470585)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of rat TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50502640(CHEMBL4470585)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)