BDBM50501292 CHEMBL3342978

SMILES c1cc(c(cc1F)OCCN2C=CC(=O)NC2=O)Oc3cc(cn4c3cc(c4)C#N)F

InChI Key InChIKey=ZZRRYEXYIVBDNM-UHFFFAOYSA-N

Data  2 IC50  2 EC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50501292   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Yale University

Curated by ChEMBL
LigandPNGBDBM50501292(CHEMBL3342978)
Affinity DataEC50:  250nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT2 cells assessed as protection against viral infection by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Yale University

Curated by ChEMBL
LigandPNGBDBM50501292(CHEMBL3342978)
Affinity DataEC50:  10nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant infected in human MT2 cells assessed as protection against viral infection by MTT ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Yale University

Curated by ChEMBL
LigandPNGBDBM50501292(CHEMBL3342978)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase p66/p51 Y181C mutant expressed in Escherichia coli BL21 (DE3) pLysS cells preincubated followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Yale University

Curated by ChEMBL
LigandPNGBDBM50501292(CHEMBL3342978)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase p66/p51 expressed in Escherichia coli BL21 (DE3) pLysS cells preincubated followed by primer/tem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)