BDBM50499310 CHEMBL3736433

SMILES CB1Nc2c(OCC(O)CN(C)C)cccc2C=C1

InChI Key InChIKey=CCSPGLLRANVKRG-UHFFFAOYSA-N

Data  32 IC50  23 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 50499310   

TargetDelta-type opioid receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type D1 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as seretonin-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human CYP1A2 by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as dopamine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as seretonin-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as EP-induced calcium by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as vassopressin-induced calcium by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced calcium by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as DPDPE-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 501nMAssay Description:Antagonist activity at human beta2 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as angiotensin-2-induced calcium by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as DAMGO-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as calcium level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as IB MECA-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 631nMAssay Description:Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as CCK8-induced calcium by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as NECA-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 398nMAssay Description:Inhibition of human CYP2D6 by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C8 by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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