BDBM50493818 Oliceridine::TRV-130::US11124523, Comparative Compound 1::US11484525, Compound TRV-130

SMILES COc1ccsc1CNCC[C@]2(CCOC3(C2)CCCC3)c4ccccn4

InChI Key InChIKey=DMNOVGJWPASQDL-UHFFFAOYSA-N

Data  6 KI  14 IC50  11 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50493818   

LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) assessed as beta arrestin-2 recruitment incubated for 3 days by PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 assessed as increase in calcium mobilization incubated for 60 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human delta opioid receptor expressed in HEK293 assessed as increase in calcium mobilization incubated for 60 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  6.70nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 assessed as increase in calcium mobilization incubated for 60 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) assessed as increase in cAMP level incubated for 40 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.50E+3nMAssay Description:To test the blocking effects of the compounds of the present disclosure on hERG potassium currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
TBA

US Patent
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 1.36E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
TBA

US Patent
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 4.60E+3nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.00E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Rat)
TBA

US Patent
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.00E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  3nMAssay Description:The experiment was performed using a cAMP detection kit from Cisbio (Cisbio #62AM4PEJ).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDelta-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at human delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of human Nav 1.5 tonic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 5.00E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human Cav 1.2 ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-Diprenorphine from human mu opiod receptor expressed in CHO cells incubated for 1 hr by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]-DAMGO from human MOR receptor expressed in HEK293T cell membrane assessed as inhibition constant incubated for 60 mins by MicroB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human mu opioid receptor by radio-ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  27nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse?Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  6.86E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D3R receptor expressed in HEK293T cell membrane assessed as inhibition constant incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse?Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  8.32E+4nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293T cell membrane assessed as inhibition constant incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed