BDBM50467711 CHEMBL4283940

SMILES c1nc2c(n1[C@@H]3CNC[C@@H]3OCP(=O)(O)O)N=C(NC2=O)N

InChI Key InChIKey=LMOOKHOOULQCAZ-UHFFFAOYSA-N

Data  3 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50467711   

TargetHypoxanthine-guanine phosphoribosyltransferase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50467711(CHEMBL4283940)
Affinity DataKi:  740nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHypoxanthine-guanine phosphoribosyltransferase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50467711(CHEMBL4283940)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant N-terminal 6His-tagged HGPRT expressed in Escherichia coli BL21 (DE3) using fixed concentration ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50467711(CHEMBL4283940)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibition of human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed