BDBM50467356 CHEMBL2418594

SMILES Cc1cc(cc(c1Nc2nc(nc(n2)OCCCN3CCOCC3)Nc4ccc(cc4)C#N)C)/C=C/C#N

InChI Key InChIKey=IRRZMAXYIYCORM-UHFFFAOYSA-N

Data  3 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50467356   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50467356(CHEMBL2418594)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of HIV1 3B reverse transcriptase infected in human MT2 cells assessed as protection against virus-induced cytopathic effect by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50467356(CHEMBL2418594)
Affinity DataEC50:  12nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT2 cells assessed as protection against virus-induced cytopathic effect by M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Wuhan Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50467356(CHEMBL2418594)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant infected in human MT2 cells assessed as protection against virus-induced cytopathi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)