BDBM50465234 CHEMBL4283787::US10766903, Example 46

SMILES Cn1nc2c(ncn(CC3(O)CCN(CC3)C(=O)C[C@H](c3ccccc3)C(F)(F)F)c2=O)c1-c1ccc(CN)cc1

InChI Key InChIKey=RLPQYKGBXQQARM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50465234   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465234(CHEMBL4283787 | US10766903, Example 46)
Affinity DataIC50: 22nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465234(CHEMBL4283787 | US10766903, Example 46)
Affinity DataIC50: 250nMAssay Description:USP7 activity was monitored in a fluorescence polarisation (FP) homogeneous assay using the isopeptide ubiquitin-Lys-TAMRA substrate (U-558, Boston B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465234(CHEMBL4283787 | US10766903, Example 46)
Affinity DataIC50: 22nMAssay Description:Inhibition of human USP7 using Ub-Rho110 as substrate by fluorescence based SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed