BDBM50462574 CHEMBL4241044

SMILES c1ccc2cc(ccc2c1)C[C@H](CC(=O)NO)n3cc(nn3)CNC(=O)c4ccc(cc4)F

InChI Key InChIKey=RASCFMYPAZDCKQ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50462574   

TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human IDE using insulin as substrate preincubated for 10 mis followed by substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant IDE harboring C110L/C171S/C178A/C257V/C414L/C573N/C590S/C789S/C812A/C819A/C904S/C966N/C974A mutant expressed in Esche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 60nMAssay Description:Inhibition of wild type human IDE catalytic site using insulin as substrate preincubated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)