BDBM50459942 CHEMBL4227864::US10730870, Example 85::US11512083, Example 85

SMILES C[C@H](NC(C)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C

InChI Key InChIKey=JKHAXURJIZDRKK-UHFFFAOYSA-N

Data  4 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50459942   

TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataKd:  440nMAssay Description:Binding affinity to VBC complex (unknown origin) by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataKd:  690nMAssay Description:Binding affinity to VBC complex (unknown origin) assessed as reduction of FAM-labelled HIF1alpha peptide binding by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataKd:  760nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50: 2.89E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50: 2.12E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50: 2.89E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459942(CHEMBL4227864 | US10730870, Example 85 | US1151208...)
Affinity DataIC50: 2.12E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent