BDBM50459055 CHEMBL4207715

SMILES NC(=N)NC(=O)c1nc(-c2cc3c(F)cccc3o2)c(nc1N)N1CCCCCC1

InChI Key InChIKey=ITMHCPYYAUUUAC-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50459055   

TargetPlasma kallikrein(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of human plasma kallikrein using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of tPA (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of activated protein C (unknown origin) using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 2.33E+4nMAssay Description:Inhibition of factor 11a (unknown origin) using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of thrombin (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of plasmin (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 430nMAssay Description:Inhibition of human kidney uPA using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of factor 10a (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50459055(CHEMBL4207715)
Affinity DataKi:  88nMAssay Description:Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed