BDBM50455480 CHEMBL4218735

SMILES CC(=O)N1c2ccc(cc2N(C[C@@H]1C3CC3)Cc4ccccc4CO)C5=CCNCC5

InChI Key InChIKey=ARWMKZDWGIOCEU-UHFFFAOYSA-N

Data  9 IC50  35 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50455480   

TargetTranscription intermediary factor 1-alpha(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TRIM24(PHD,Bromo.) expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetATPase family AAA domain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged ATAD2A expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain adjacent to zinc finger domain protein 2A(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BAZ2A expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BRD1 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BRD9 isoform 1 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged CECR2 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged EP300 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged GCN5L2 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged SMARCA2 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1-like(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TAF1L BD2 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNucleosome-remodeling factor subunit BPTF(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged FALZ isoform1 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain and WD repeat-containing protein 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  1.51E+4nMAssay Description:Binding affinity to human partial length DNA-tagged WRD9 BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  1.55E+3nMAssay Description:Binding affinity to human partial length DNA-tagged BRD4 isoform long BD1 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase TRIM33(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TRIM33(PHD,Bromo.) expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 50nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  1.86E+3nMAssay Description:Binding affinity to human partial length DNA-tagged BRDT isoform b BD1 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BAZ2B expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PBRM1 BD5 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  1.32E+3nMAssay Description:Binding affinity to human partial length DNA-tagged BRD2 isoform 1 BD1 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  3.00E+3nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) (N44 to E168 residues) expressed in bacterial expression system assessed as dissociation constant by BROMOsca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  63nMAssay Description:Inhibition of BRD4-BD2 (unknown origin) (K333 to E460 residues) expressed in bacterial system assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged CREBBP expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPeregrin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  2.46E+3nMAssay Description:Binding affinity to human partial length DNA-tagged BRPF1 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PCAF expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 3.16E+3nMAssay Description:Displacement of (+)-JQ1 from 6H-Thr BRD4 Y390A mutant BD1 (unknown origin) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain and PHD finger-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BRPF3 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 63nMAssay Description:Displacement of (+)-JQ1 from 6H-Thr BRD4 Y97A mutant BD2 (unknown origin) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of BRDT BD1 (unknown origin) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  912nMAssay Description:Binding affinity to human partial length DNA-tagged BRD3 BD1 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  1.45E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TAF1 BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetATPase family AAA domain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged ATAD2B expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 8(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to DNA-tagged BRD8 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription activator BRG1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged SMARCA4 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PBRM1 BD1 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  21nMAssay Description:Binding affinity to human partial length DNA-tagged BRDT isoform b BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 7(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BRD7 expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human BRD2 BD1 after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 316nMAssay Description:Inhibition of human BRD2 BD2 after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 200nMAssay Description:Inhibition of BRDT BD2 (unknown origin) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPeregrin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of Alexa 647 ligand from 6H-Flag-Tev-BRPF1 (622 to 738 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  6.60nMAssay Description:Binding affinity to human partial length DNA-tagged BRD4 isoform long BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  32nMAssay Description:Binding affinity to human partial length DNA-tagged BRD2 isoform 1 BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd:  19nMAssay Description:Binding affinity to human partial length DNA-tagged BRD3 BD2 expressed in bacterial by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed