BDBM50453950 CHEMBL4203082::US11247989, Example 88

SMILES CC(=O)N1CCc2c(c(nn2C3CCOCC3)c4cccc5c4cnc(c5)c6cnn(c6)C)C1

InChI Key InChIKey=RPDQYBNAJDAGIK-UHFFFAOYSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50453950   

TargetBromodomain-containing protein 4(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataEC50:  32nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50: 1.16nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)